FREE SHIPPING ON $60+, FREE RETURN ON ALL ORDERS. Details.

Since 2012, Daniel Alain has ardently pursued the research and development for solutions to women’s hair loss, leading to technology innovations, the acquisition of numerous US and International patent rights and the funding of several studies that have been published in peer-reviewed medical journals. 

Daniel Alain has a long-standing partnership with biotech company Applied Biology, investing over 10 million dollars on advancing technology and procuring solutions to women’s hair loss. No other hair loss company invests so heavily in supporting women’s hair loss or offers such a comprehensive portfolio of products to address hair loss from all angles.

In 2020 Daniel Alain acquired a stake in Applied Biology, further solidifying the commitment to the continued discovery of advanced solutions to women’s hair loss.

Daniel Alain sits at the helm of introducing diagnostics that will forever change the landscape of how we treat women’s hair loss, ushering in a new era.

Identifying hair loss cause and treatment response will help millions of women take preventative measures and take control of hair loss – saving time, money and emotional stress so they can live life to the fullest. 

2020

Safety measures in dermatology help minimize spread of COVID-19.

Goren A, Rathod D, Kroumpouzos G, Jafferany M, Goldust M.
Dermatol Ther. 2020 Jun 7. doi: 10.1111/dth.13773. Online ahead of print.

Read More...

2020

Microneedling improves minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes.

Kovacevic M, Goren A, Shapiro J, Sinclair R, Lonky NM, Situm M, Bulat V, Bolanca Z, McCoy J.
Dermatol Ther. 2016 Oct 6. doi: 10.1111/dth.12415.

Read More...

2020

Androgenetic alopecia present in the majority of hospitalized COVID-19 patients - the "Gabrin sign".

Wambier CG, Vaño-Galván S, McCoy J, Gomez-Zubiaur A, Herrera S, Hermosa-Gelbard Á, Moreno-Arrones OM, Jiménez-Gómez N, González-Cantero A, Pascual PF, Segurado-Miravalles G, Shapiro J, Pérez-García B, Goren A.
J Am Acad Dermatol. 2020 May 21:S0190-9622(20)30948-8. doi: 10.1016/j.jaad.2020.05.079. Online ahead of print.

Read More...

2020

Novel topical booster enhances follicular sulfotransferase activity in patients with androgenetic alopecia: A new strategy to improve minoxidil response.

Ramos PM, McCoy J, Wambier C, Shapiro J, Vañó-Galvan S, Sinclair R, Goren A.
J Eur Acad Dermatol Venereol. 2020 May 20. doi: 10.1111/jdv.16645. Online ahead of print.

Read More...

2020

Androgen sensitivity gateway to COVID-19 disease severity.

Wambier CG, Goren A, Vaño-Galván S, Ramos PM, Ossimetha A, Nau G, Herrera S, McCoy J.
Drug Dev Res. 2020 May 15:10.1002/ddr.21688. doi: 10.1002/ddr.21688. Online ahead of print.

Read More...

2020

Topical alpha-1 adrenergic receptor agonist applied to the nipple/areola complex improves female orgasmic function.

Goren A, McCoy J, Krychman M, Brandt L, Lah A, Lonky N.
J Womens Health (Larchmt). 2020 May 12. doi: 10.1089/jwh.2019.8188. Online ahead of print.

Read More...

2020

Allergic contact dermatitis in patients with frontal fibrosing alopecia: An international multi-center study.

Rudnicka L, Rokni GR, Lotti T, Wollina U, Fölster-Holst R, Katsambas A, Goren A, Di Lernia VG, Rathod D, Mirabi A, Ghaffari A, Rajan A, Goldust M.
Dermatol Ther. 2020 May 12:e13560. doi: 10.1111/dth.13560. Online ahead of print.

Read More...

2020

Novel yeast extract is superior to colloidal oatmeal in providing rapid itch relief.

Dhurat R, Sharma A, Surve R, McCoy J, Kovacevic M, Goren A, Tan Y, Zou Y, Goldust M, Situm M, Stanimirovic A.
J Cosmet Dermatol. 2020 May 2. doi: 10.1111/jocd.13436. Online ahead of print.

Read More...

2020

Racial variations in COVID-19 deaths may be due to androgen receptor genetic variants associated with prostate cancer and androgenetic alopecia. Are anti-androgens a potential treatment for COVID-19?

Goren A, Vaño-Galván S, Wambier CG, McCoy J, Gomez-Zubiaur A, Moreno-Arrones OM, Shapiro J, Sinclair RD, Gold MH, Kovacevic M, Mesinkovska NA, Goldust M, Washenik K.
J Cosmet Dermatol. 2020 Apr 16. doi: 10.1111/jocd.13443. Online ahead of print.

Read More...

2020

A preliminary observation: Male pattern hair loss among hospitalized COVID-19 patients in Spain - A potential clue to the role of androgens in COVID-19 severity.

Goren A, Vaño-Galván S, Wambier CG, McCoy J, Gomez-Zubiaur A, Moreno-Arrones OM, Shapiro J, Sinclair RD, Gold MH, Kovacevic M, Mesinkovska NA, Goldust M, Washenik K.
J Cosmet Dermatol. 2020 Apr 16. doi: 10.1111/jocd.13443. Online ahead of print.

Read More...

2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated.

Wambier CG, Goren A.
J Am Acad Dermatol. 2020 Apr 10:S0190-9622(20)30608-3. doi: 10.1016/j.jaad.2020.04.032. Online ahead of print.

Read More...

2020

What does androgenetic alopecia have to do with COVID-19? An insight into a potential new therapy.

Goren A, McCoy J, Wambier CG, Vano-Galvan S, Shapiro J, Dhurat R, Washenik K, Lotti T.
Dermatol Ther. 2020 Apr 1:e13365. doi: 10.1111/dth.13365. Online ahead of print.

Read More...

2020

STAT3-mutated hyperimmunoglobulin E syndrome with perianal skin tags and erosions: A case report.

Fölster-Holst R, Kazeminejad A, Rokni GR, Lotti T, Goren A, Goldust M.
Dermatol Ther. 2020 Mar 26:e13333. doi: 10.1111/dth.13333. Online ahead of print.

Read More...

2020

Low-level laser therapy and narrative review of other treatment modalities in androgenetic alopecia.

Galadari H, Shivakumar S, Lotti T, Wollina U, Goren A, Rokni GR, Grabbe S, Goldust M.
Lasers Med Sci. 2020 Mar 11. doi: 10.1007/s10103-020-02994-4. Online ahead of print.

Read More...

2020

Erosive pustular dermatosis of the scalp: a multicentre study.

Starace M, Iorizzo M, Trüeb RM, Piccolo V, Argenziano G, Camacho FM, Gallyamova Y, Rudnicka L, Umbert I, Lyakhovitsky A, Vañó-Galván S, Goren A, Alessandrini A, Bruni F, Piraccini BM.
J Eur Acad Dermatol Venereol. 2020 Jan 18. doi: 10.1111/jdv.16211. Online ahead of print.

Read More...

2020

Yeast extract demonstrates rapid itch relief in chronic pruritus.

Zhang Y, Tan Y, Zou Y, Bulat V, Lugovic Mihic L, Kovacevic M, Lotti T, Verner I, Stanimirovic A, Situm M, Goldust M, Liu W, Vojvodic A, Goren A.
J Cosmet Dermatol. 2020 Jan 10. doi: 10.1111/jocd.13265. Online ahead of print.

Read More...

2020

Non-ablative radio frequency for the treatment of androgenetic alopecia.

Tan Y, Wei L, Zhang Y, Goren A, McCoy J, Stanimirovic A, Lotti T, Kovacevic M.
Acta Dermatovenerol Alp Pannonica Adriat. 2019 Dec;28(4):169-171.

Read More...

2020

Can we halt male androgenetic alopecia progression without antiandrogenic drugs?

Zhang Y, Tan Y, Zou Y, Bulat V, Lugovic Mihic L, Kovacevic M, Lotti T, Verner I, Stanimirovic A, Situm M, Goldust M, Liu W, Vojvodic A, Goren A.
J Cosmet Dermatol. 2020 Jan 10. doi: 10.1111/jocd.13265. Online ahead of print.

Read More...

2020

Novel topical formulation applied to the nipple-areola complex improves female orgasm.

Krychman M, Goren A, Brandt L, McCoy J.
J Cosmet Dermatol. 2020 Feb;19(2):404-406. doi: 10.1111/jocd.13262. Epub 2019 Dec 17.

Read More...

2020

Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients.

Ramos PM, Sinclair R, Miot HA, Goren A.
Dermatol Ther. 2020 Jan;33(1):e13195. doi: 10.1111/dth.13195. Epub 2019 Dec 27.

Read More...

2020

Efficacy of topical latanoprost in the treatment of eyelid vitiligo: A randomized, double-blind clinical trial study.

Nowroozpoor Dailami K, Hosseini A, Rahmatpour Rokni G, Saeedi M, Morteza-Semnani K, Sadeghi Z, Ghasemzadeh Diva SM, Goldust M, Lotti T, Vojvodic A, Goren A, Sonthalia S, Rathod D.
Dermatol Ther. 2020 Jan;33(1):e13175. doi: 10.1111/dth.13175. Epub 2019 Dec 26.

Read More...

2020

Vemurafenib and cobimetinib-induced toxic epidermal necrolysis in a patient with metastatic melanoma.

Poduje S, Brozić JM, Prkačin I, Delaš Aždajić M, Goren A.
Dermatol Ther. 2020 Jan;33(1):e13174. doi: 10.1111/dth.13174. Epub 2019 Dec 11.

Read More...

2020

The impact of short tandem repeat variation on gene expression.

Fotsing SF, Margoliash J, Wang C, Saini S, Yanicky R, Shleizer-Burko S, Goren A, Gymrek M.
Nat Genet. 2019 Nov;51(11):1652-1659. doi: 10.1038/s41588-019-0521-9. Epub 2019 Nov 1.

Read More...

2020

Oral minoxidil bio-activation by hair follicle outer root sheath cell sulfotransferase enzymes predicts clinical efficacy in female pattern hair loss.

Ramos PM, Goren A, Sinclair R, Miot HA.
J Eur Acad Dermatol Venereol. 2020 Jan;34(1):e40-e41. doi: 10.1111/jdv.15891. Epub 2019 Sep 11.

Read More...

2019

Radio frequency in the treatment of androgenetic alopecia.

Goren et al.
Journal of Cosmetic Dermatology (Submitted 2019)

2019

Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine associate receptor.

Goren et al.
Journal of Cosmetic Dermatology (Accepted 2019)

Read More...

2019

Evaluation of the diabetogenic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome, a pilot study.

Dehpouri et al.
Dermatology Reports 2019; volume 11:7965

2019

Mission impossible: Dermal delivery of growth factors via microneedling.

Dhurat R, Sharma A, Goren A, Daruwalla S, Situm M, Kovacevic M.
J.Dermatol Ther. (Accepted 2019)

2019

Tretinoin enhances minoxidil response in androgenetic alopecia patients by up-regulating follicular sulfotransferase enzymes.

Aseem Sharma, Andy Goren, Rachita Dhurat, Sandip Agrawal, Rodney Sinclair, Ralph Trueb, Sergio Vano-Galvan, Guangping Chen, Yamili Tan, Maja Kovacevic, Mirna Situm, John McCoy.
J.Dermatol Ther. (Accepted 2019)

2019

Identification of the sulfotransferase iso-Enzyme primarily responsible for the bio-activation of topical minoxidil.

J McCoy, A Goren, T Naccarato1, M Kovacevic, M Situm, VL Skudar, T Lotti.
J Biol Regul Homeost Agents (Pending Publication).

2019

History of vitiligo.

Kovacevic Maja, Franceschi Nika, Situm Mirna, Goren Andy, Stanimirovic Andrija, Valle Yan, Lotti Torello.
Springer (Pending Publication).

2019

Platelet rich plasma in androgenetic alopecia: A systematic review.

Lotti T., Goren A., Verner I. d’Alessio P., Franca K.
J.Dermatol Ther. (Pending Publication).

2019

Integrative dermatology: The microbiome in hair disorders.

Goren A, Situm M, Kovacevic M, McCoy J, Lotti T.
Wiley (Pending Publication).

2018 November

Frontal pattern hair loss among Chinese women is frequently associated with ponytail hairstyle.

Goren A. Wei L., Yimei T., Kovacevic M., McCoy J., Lotti T.
Dermatol Ther. 2018 Nov 20:e12784. doi: 10.1111/dth.12784.

Read More...

2018 October

Low dose daily aspirin reduces topical minoxidil efficacy in androgenetic alopecia patients.

Goren A., Sharma A., Dhurat R., Shapiro J., Sinclair R., Situm M., Kovacevic M., Skudar L V., Goldust M.,Lotti T., McCoy J.
Dermatol Ther. 2018 Nov;31(6):e12741. doi: 10.1111/dth.12741. Epub 2018 Oct 8.

Read More...

2018 July

Anterior, frontal congenital triangular alopecia, redundancy in therapy without improvement; A case report.

Goldust M, Rokni G, Sadr S, Mirabi A, Goren A, Lotti T.
J.Dermatol Ther. (Accepted July 24, 2018)

Read More...

2018 July

Minoxidil in the treatment of androgenetic alopecia.

Goren A., Naccarato T.
J.Dermatol Ther. (Accepted July 16, 2018)

Read More...

2018 July

Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients in Indian subcontinent.

Jill Chitalia, MD, Rachita Dhurat, MD, Andy Goren, MD, John McCoy, PhD, Maja Kovacevic, MD, Mirna Situm, MD, Ty Naccarato, Torello Lotti, MD
J.Dermatol Ther. (Accepted July 10, 2018)

Read More...

2018 June

Characterization of follicular minoxidil sulfotransferase activity in a cohort of pattern hair loss patients in Indian subcontinent

Jill Chitalia, MD, Rachita Dhurat, MD, Andy Goren, MD, John McCoy, PhD, Maja Kovacevic, MD, Mirna Situm, MD, Ty Naccarato, Torello Lotti, MD
J.Dermatol Ther. (Accepted July 10, 2018)

Read More...

2018 June

The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity.

Goren A, McCoy J, Kovacevic M, Situm M, Chitalia J, Dhurat R, Naccarato T, Lotti T.
J Biol Regul Homeost Agents. (Accepted June 11, 2018)

Read More...

2018 June

Controversies in the treatment of androgenetic alopecia: The history of finasteride.

JGoren A, McCoy J, Situm M, Dhurat R, Krychman M, Kovacevic M, Sharma A, Bolanca Z.
J.Dermatol Ther. (Accepted June 12, 2018)

Read More...

2018 January

Micro-focused phototherapy associated to Janus Kinase inhibitor: A promising valid therapeutic option for patient with localized vitiligo.

Gianfaldoni S, Tchernev G, Wollina U, Roccia MG, Fioranelli M, Lotti J, Rovesti M, Satolli F, Valle Y, Goren A, Tirant M, Situm M, Kovacevic M, França K, Lotti T.
Open Access Maced J Med Sci. 2018 Jan 21;6(1):46-48. doi: 10.3889/oamjms.2018.042. eCollection 2018 Jan 25. PubMed PMID: 29483979; PubMed Central PMCID: PMC5816312.

Read More...

2017 October - December

Social selection favours offspring prone to the development of androgenetic alopecia.

Goren A, Shapiro J, Naccarato T, Situm M, Kovacevic M, Lonky N, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1013-1016. PubMed PMID: 29254307.

Read More...

2017 October - December

Mechanism of action of minoxidil in the treatment of androgenetic alopecia is likely mediated by mitochondrial adenosine triphosphate synthase-induced stem cell differentiation.

Goren A, Naccarato T, Situm M, Kovacevic M, Lotti T, McCoy J.
2017 Oct-Dec;31(4):1049-1053. PubMed PMID: 29254313.

Read More...

2017 July - September

Potential risk of developing herpes simplex encephalitis in patients treated with sildenafil following primary exposure to genital herpes.

Goren A, McCoy J, Kovacevic M, Situm M, Lonky N.
J Biol Regul Homeost Agents. 2017 Jul-Sep;31(3):679-682. PubMed PMID: 28956417.

Read More...

2017 March

Novel technique for repigmentation of senescence grey hair.

Goren A, Bolanča Ž, Lotti T, Šitum M.
Dermatol Ther. 2017 Mar;30(2). doi: 10.1111/dth.12436. Epub 2016 Dec 5. PubMed PMID: 27917579.

Read More...

2017 January - March

Melanin of the nipple areola complex.

Goren A, Kovacevic M, Lotti T.
J Biol Regul Homeost Agents. 2017 Jan-Mar;31(1):237-238. PubMed PMID: 28337898.

Read More...

2016 October - December

Minoxidil dose response study in female pattern hair loss patients determined to be non-responders to 5% topical minoxidil.

McCoy J, Goren A, Kovacevic M, Shapiro J.
2016 Oct-Dec;30(4):1153-1155. PubMed PMID: 28078868.

Read More...

2016 October

Prevalence of hair shedding among women.

Kovacevic M, Goren A, Shapiro J, Sinclair R, Lonky NM, Situm M, Bulat V, Bolanca Z, McCoy J.
Dermatol Ther. 2016 Oct 6. doi: 10.1111/dth.12415.

Read More...

2016 July

Platelet-rich plasma as a novel treatment for lichen panopillaris.

Bolanča Ž, Goren A, Getaldić-Švarc B, Vučić M, Šitum M.
Dermatol Ther. 2016 Jul;29(4):233-5.

Read More...

2016 July

Mixed vitiligo of blaschko lines: a newly discovered presentation of vitiligo responsive to combination treatment.

Kovacevic M, Stanimirovic A, Vucic M, Goren A, Situm M, Lukinovic Skudar V, Lotti T.
Dermatol Ther. 2016 Jul;29(4):240-3.

Read More...

2016 March

α1-AR Agonist induced piloerection protects against the development of traction alopecia.

Goren A, Shapiro J, Sinclair R, Kovacevic M, McCoy J.
Dermatol Ther. 2016 May;29(3):160-3.

Read More...

2016 March

Platelet-rich plasma as a novel treatment for lichen planopillaris.

Bolanča Ž, Goren A, Getaldić-Švarc B, Vučić M, Šitum M.
Dermatol Ther. 2016 Jul;29(4):233-5. doi: 10.1111/dth.12343. Epub 2016 Mar 14. PubMed PMID: 26988129.

Read More...

2016 January - March

Doppler laser imaging predicts response to topical Minoxidil in the treatment of female pattern hair loss.

McCoy J, Kovacevic M, Situm M, Stanimirovic A, Bolanca Z, Goren A.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):131-4.

Read More...

2015

ProDrugs in dermatology.

Goren A, McCoy J, Lotti T.
European Handbook of Dermatological Treatments. 2015. ISBN 978-3-662-45139-7.

2015 December

Melanocytes precursor cells as a novel treatment for vitiligo.

Zanardelli M, Goren A, Lotti T.
G Ital Dermatol Venereol. 2015 Dec 23.

Read More...

2015 January - February

Clinical utility and validity of Minoxidil response testing in androgenetic alopecia.

Goren A, Shapiro J, Roberts J, McCoy J, Desai N, Zarrab Z, Pietrzak A, Lotti T.
Dermatol Ther. 2015 Jan-Feb;28(1):13-6.

Read More...

2014 September - October

Novel topical cream delivers safe and effective alternative to traditional psoriasis phototherapy.

Goren A, Salafia A, McCoy J, Keene S, Lotti T, Petrusevska A.
Dermatol Ther. 2014 Sep-Oct;27(5):260-3.

Read More...

2014 July - August

Sulfotransferase activity in plucked hair follicles predicts response to topical Minoxidil in the treatment of female androgenetic alopecia.

Roberts J, Desai N, McCoy J, Goren A.
Dermatol Ther. 2014 Jul-Aug;27(4):252-4.

Read More...

2014 July - August

Novel topical cream delivers safe and effective sunlight therapy for vitiligo by selectively filtering damaging ultraviolet radiation.

Goren A, Salafia A, McCoy J, Keene S, Lotti T.
Dermatol Ther. 2014 Jul-Aug;27(4):195-7.

Read More...

2014 May - June

Acute telogen effluvium onset event is associated with the presence of female androgenetic alopecia: potential therapeutic implications.

Perez-Mora N, Goren A, Velasco C, Bermudez F.
Dermatol Ther. 2014 May-Jun;27(3):159-62.

Read More...

2014 May - June

Novel enzymatic assay predicts minoxidil response in the treatment of androgenetic alopecia.

Goren A, Castano JA, McCoy J, Bermudez F, Lotti T.
Dermatol Ther. 2014 May-Jun;27(3):171-3.

Read More...

2014 March - April

In vitro evaluation of a novel topical cream for vitiligo and psoriasis that selectively delivers NB-UVB therapy when exposed to sunlight.

McCoy J, Goren A, Lotti T.
Dermatol Ther. 2014 Mar-Apr;27(2):117-20.

Read More...

2011 March - April

Therapeutic hotline. Genetic variations in the androgen receptor gene and finasteride response in women with androgenetic alopecia mediated by epigenetics.

Keene S, Goren A.
Dermatol Ther. 2011 Mar-Apr;24(2):296-300.

Read More...